{"id":27909,"date":"2025-04-29T15:32:36","date_gmt":"2025-04-29T18:32:36","guid":{"rendered":"https:\/\/agencia.unq.edu.ar\/?p=27909"},"modified":"2025-04-29T15:34:08","modified_gmt":"2025-04-29T18:34:08","slug":"dolor-cronico-descubren-que-los-trasplantes-fecales-podrian-brindar-alivio","status":"publish","type":"post","link":"https:\/\/agencia.unq.edu.ar\/?p=27909","title":{"rendered":"Dolor cr\u00f3nico: descubren que los trasplantes fecales podr\u00edan brindar alivio"},"content":{"rendered":"\n<p class=\"has-medium-font-size wp-block-paragraph\">Los microorganismos presentes en el sistema digestivo podr\u00edan ser parte de futuros tratamientos. Aunque faltan m\u00e1s ensayos, las primeras pruebas resultaron auspiciosas. <\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1040\" height=\"420\" src=\"https:\/\/agencia.unq.edu.ar\/wp-content\/uploads\/2025\/04\/Fibromialgia.jpg\" alt=\"Una de las afecciones de dolor cr\u00f3nico m\u00e1s com\u00fan es la fibromialgia (cr\u00e9ditos: Universidad de Chile)\" class=\"wp-image-27910\"\/><figcaption class=\"wp-element-caption\">Una de las afecciones de dolor cr\u00f3nico m\u00e1s com\u00fan es la fibromialgia (cr\u00e9ditos: Universidad de Chile)<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Un grupo de investigadores de diversas instituciones de Canad\u00e1 e Israel estudi\u00f3 la influencia de la microbiota en el dolor cr\u00f3nico. Al realizar un trasplante de microorganismos del sistema digestivo de pacientes con fibromialgia (una afecci\u00f3n com\u00fan relacionada al dolor) a ratones libres de g\u00e9rmenes, los animales comenzaron a sentir dolor tambi\u00e9n. Mas adelante, <strong>esos mismos animales fueron tratados mediante otro trasplante de microbiota, esta vez de individuos sanos. Esta segunda transferencia de microorganismos logr\u00f3 que los animales experimentaran alivio.<\/strong> Los resultados fueron publicados en un reciente art\u00edculo de la revista <a href=\"https:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273(25)00252-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627325002521%3Fshowall%3Dtrue\" target=\"_blank\" rel=\"noopener\" title=\"\">Neuron<\/a> al que la <a href=\"https:\/\/agencia.unq.edu.ar\/\" target=\"_blank\" rel=\"noopener\" title=\"\">Agencia de Noticias Cient\u00edficas de la Universidad Nacional de Quilmes<\/a> tuvo acceso.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El dolor cr\u00f3nico es una enfermedad com\u00fan y debilitante. Aunque puede desencadenarse por una lesi\u00f3n en los tejidos o alguna enfermedad, tambi\u00e9n aparece sin patolog\u00edas que lo expliquen. <strong>La afecci\u00f3n m\u00e1s com\u00fan de dolor cr\u00f3nico sin da\u00f1o tisular es la fibromialgia<\/strong> y afecta al cuatro por ciento de la poblaci\u00f3n mundial, especialmente a las mujeres. Los mecanismos detr\u00e1s de esta condici\u00f3n son a\u00fan desconocidos, por lo que sus opciones de tratamiento tambi\u00e9n son escasas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">En trabajos previos, los especialistas que llevaron adelante el estudio publicado en Neuron observaron que <strong>la composici\u00f3n de la microbiota en personas con fibromialgia era diferente respecto de personas sin ella<\/strong>. De all\u00ed surgi\u00f3 la idea de evaluar qu\u00e9 era lo que estos microorganismos causaban en ratones para poder estudiar tambi\u00e9n otros componentes y esbozar alguna posible terapia. La microbiota de individuos sanos o con dolor cr\u00f3nico se incorpor\u00f3 a los intestinos de los ratones mediante trasplante fecal. Es un procedimiento en el que los microorganismos se extraen de las heces y luego se transfieren. En la actualidad se aplica en seres humanos, en concreto, en pacientes con infecciones bacterianas resistentes a antibi\u00f3ticos. Las v\u00edas de administraci\u00f3n var\u00edan de acuerdo a los requerimientos m\u00e9dicos.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">En el estudio se demostr\u00f3 que el trasplante de microbiota de personas con fibromialgia tambi\u00e9n caus\u00f3 cambios en c\u00e9lulas y mol\u00e9culas del sistema inmune. <strong>En ratones trasplantados que experimentaban dolor se observ\u00f3 un aumento de linfocitos T activados<\/strong>, c\u00e9lulas que son parte del ej\u00e9rcito que utiliza el cuerpo para combatir enfermedades. Adem\u00e1s, <strong>se increment\u00f3 la concentraci\u00f3n de Interleucina 17 o IL-17<\/strong>, una mol\u00e9cula que est\u00e1 implicada en el incremento de inflamaci\u00f3n. En conjunto, la microbiota de individuos con dolor cr\u00f3nico favoreci\u00f3 procesos inflamatorios en los ratones. Los mismos se redujeron luego del trasplante fecal de individuos sanos.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Los avances recientes en la comprensi\u00f3n de las funciones clave de la microbiota intestinal en el dolor cr\u00f3nico impulsaron <strong>intervenciones como el trasplante, el tratamiento con componentes derivados de la materia fecal o el uso de probi\u00f3ticos.<\/strong> Los investigadores explicaron que estos tratamientos pueden dar respuesta a un problema que afecta a la salud f\u00edsica y emocional ya que <strong>un problema que acompa\u00f1a al dolor cr\u00f3nico es la depresi\u00f3n<\/strong>. En este sentido, se realiz\u00f3 un ensayo en mujeres con fibromialgia a quienes se las someti\u00f3 a un trasplante de materia fecal de individuos sanos. Aunque se observ\u00f3 una reducci\u00f3n del dolor y una mejora general de la calidad de vida, los cient\u00edficos resaltan que a\u00fan faltan m\u00e1s controles para asegurar la efectividad del tratamiento.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Por desagradable que suene, la materia fecal de personas sanas ayudar\u00eda, en un futuro cercano, a calmar el dolor cr\u00f3nico<\/strong> y as\u00ed dar respuestas a un problema complejo de salud f\u00edsica y emocional.<\/p>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-e31d8b4a alignwide uagb-is-root-container\">\n<div class=\"wp-block-uagb-advanced-heading uagb-block-ead76a57\"><h4 class=\"uagb-heading-text\">\u00daltimas noticias de la secci\u00f3n Ciencias:<\/h4><\/div>\n\n\n\n\t\t\t<div class=\"wp-block-uagb-post-carousel uagb-post-grid  uagb-post__image-position-top uagb-post__image-enabled uagb-block-24e22604     uagb-post__arrow-outside uagb-slick-carousel uagb-post__items uagb-post__columns-3 is-carousel uagb-post__columns-tablet-2 uagb-post__columns-mobile-1\" data-total=\"70\" style=\"\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<div class='uagb-post__image'>\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/agencia.unq.edu.ar\/?p=40068\" target=\"_self\" rel=\"bookmark noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"960\" height=\"388\" src=\"https:\/\/agencia.unq.edu.ar\/wp-content\/uploads\/2026\/11\/Una-nina-Toba_Qom-duerme-en-una-hamaca.-La-foto-pertenece-a-una-investigacion-anterior-sobre-el-vinculo-entre-el-acceso-a-la-electricidad-y-el-sueno.-Credito_-Universidad-de-Washington.jpg\" class=\"attachment-medium size-medium\" alt=\"Una ni\u00f1a Toba duerme en una hamaca. Cr\u00e9dito: Universidad de Washington.\" \/>\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/agencia.unq.edu.ar\/?p=40068\" target=\"_self\" rel=\"bookmark noopener noreferrer\">Electricidad, celulares y sue\u00f1o: cient\u00edficos estudian qu\u00e9 cambia en comunidades Toba\/Qom de la Argentina<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<div class='uagb-post__image'>\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/agencia.unq.edu.ar\/?p=39943\" target=\"_self\" rel=\"bookmark noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"960\" height=\"388\" src=\"https:\/\/agencia.unq.edu.ar\/wp-content\/uploads\/2026\/10\/Base-Carlini-Antartida.jpg\" class=\"attachment-medium size-medium\" alt=\"La Base Carlini es considerada como una usina cient\u00edfica de la Ant\u00e1rtida Argentina. Cr\u00e9ditos: Instituto Ant\u00e1rtico Argentino.\" \/>\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/agencia.unq.edu.ar\/?p=39943\" target=\"_self\" rel=\"bookmark noopener noreferrer\">Carrera espacial: \u00bfqui\u00e9n es el cient\u00edfico argentino que investiga desde la Ant\u00e1rtida los desaf\u00edos f\u00edsicos y ps\u00edquicos de viajar a Marte?<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<div class='uagb-post__image'>\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/agencia.unq.edu.ar\/?p=39863\" target=\"_self\" rel=\"bookmark noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"960\" height=\"388\" src=\"https:\/\/agencia.unq.edu.ar\/wp-content\/uploads\/2026\/10\/Tambora-Principal.jpg\" class=\"attachment-medium size-medium\" alt=\"La erupci\u00f3n del Tambora fue la m\u00e1s fuerte registrada hasta el presente (cr\u00e9ditos: CNN en espa\u00f1ol)\" \/>\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/agencia.unq.edu.ar\/?p=39863\" target=\"_self\" rel=\"bookmark noopener noreferrer\">Tambora, el volc\u00e1n en Indonesia que se rob\u00f3 el verano europeo<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<div class='uagb-post__image'>\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/agencia.unq.edu.ar\/?p=39852\" target=\"_self\" rel=\"bookmark noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"960\" height=\"388\" src=\"https:\/\/agencia.unq.edu.ar\/wp-content\/uploads\/2026\/10\/Imperio-inca-argentina-catamarca.jpg\" class=\"attachment-medium size-medium\" alt=\"El Shincal de Quimivil, una capital del Imperio Inca en Catamarca. Cr\u00e9ditos: Fundaci\u00f3n Azara.\" \/>\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/agencia.unq.edu.ar\/?p=39852\" target=\"_self\" rel=\"bookmark noopener noreferrer\">Tras las huellas del imperio inca: el Conicet transmitir\u00e1 una excavaci\u00f3n en Catamarca<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<div class='uagb-post__image'>\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/agencia.unq.edu.ar\/?p=39835\" target=\"_self\" rel=\"bookmark noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"504\" height=\"204\" src=\"https:\/\/agencia.unq.edu.ar\/wp-content\/uploads\/2026\/11\/2026-10-27-Biosphera-Luis-Wall.jpg\" class=\"attachment-medium size-medium\" alt=\"Luis Wall durante la presentaci\u00f3n de su proyecto Bi\u00f6sphera. Cr\u00e9ditos: Gentileza Valeria Segatori.\" \/>\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/agencia.unq.edu.ar\/?p=39835\" target=\"_self\" rel=\"bookmark noopener noreferrer\">Cient\u00edfico de la UNQ gan\u00f3 un concurso internacional sobre innovaci\u00f3n y ciencia<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<div class='uagb-post__image'>\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/agencia.unq.edu.ar\/?p=39797\" target=\"_self\" rel=\"bookmark noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"504\" height=\"204\" src=\"https:\/\/agencia.unq.edu.ar\/wp-content\/uploads\/2026\/11\/2026-10-23-Luis-Wall-Biosfera-1.jpg\" class=\"attachment-medium size-medium\" alt=\"Luis Wall durante la presentaci\u00f3n de Bi\u00f6sphera en el Crossing Over 2026. Cr\u00e9ditos: Gentileza Luis Wall.\" \/>\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/agencia.unq.edu.ar\/?p=39797\" target=\"_self\" rel=\"bookmark noopener noreferrer\">Cient\u00edfico de la UNQ es finalista de un concurso internacional sobre innovaci\u00f3n y ciencia<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<div class='uagb-post__image'>\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/agencia.unq.edu.ar\/?p=39698\" target=\"_self\" rel=\"bookmark noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"960\" height=\"388\" src=\"https:\/\/agencia.unq.edu.ar\/wp-content\/uploads\/2026\/10\/Perros-principal.jpg\" class=\"attachment-medium size-medium\" alt=\"Las respuestas del envejecimiento aparecen de la mano de los patrones de metilaci\u00f3n del ADN (imagen: mascotas.com)\" \/>\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/agencia.unq.edu.ar\/?p=39698\" target=\"_self\" rel=\"bookmark noopener noreferrer\">\u00bfQu\u00e9 sabe la ciencia sobre el envejecimiento de las mascotas m\u00e1s leales?<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article class=\"uagb-post__inner-wrap\">\t\t\t\t\t\t\t\t<div class='uagb-post__image'>\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/agencia.unq.edu.ar\/?p=39594\" target=\"_self\" rel=\"bookmark noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"504\" height=\"204\" src=\"https:\/\/agencia.unq.edu.ar\/wp-content\/uploads\/2026\/10\/2026-10-14-Cecilia-Jarne-.jpg\" class=\"attachment-medium size-medium\" alt=\"Cecilia Jarne fue parte de un equipo de 50 cient\u00edficos que desarrollaron un modelo con IA para prevenir enfermedades neurodegenerativas a trav\u00e9s de la voz. Cr\u00e9ditos: @ceciliajarne.\" \/>\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<h4 class=\"uagb-post__title uagb-post__text\">\n\t\t\t\t<a href=\"https:\/\/agencia.unq.edu.ar\/?p=39594\" target=\"_self\" rel=\"bookmark noopener noreferrer\">Cient\u00edfica de la UNQ particip\u00f3 de un estudio novedoso que identifica el deterioro cognitivo a partir del habla<\/a>\n\t\t\t<\/h4>\n\t\t\t\t\t\t<div class='uagb-post__text uagb-post-grid-byline'>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Los mircoorganismos presentes en el sistema digestivo podr\u00edan ser parte de futuros tratamientos. <\/p>\n","protected":false},"author":8,"featured_media":27910,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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